Grand Challenges Rwanda program will be implemented by the NCST with facilitation and implementation of projects by a dedicated team from the Secretariat of the Grand Challenges Rwanda. The Board of NCST Council Members will oversee the overall implementation providing advisory and overall oversight to ensure that GC Rwanda complies with the requisite impact- based outcome as well as accountability, good governance and sustainability of the program.

Three Board of NRIF sub-committee that is instituted to provide technical and scientific guidance on research and innovation funded will advise the GC Secretariat on research call priorities, and after technical reviews of the applications, approve recommended research projects for final funding based on budget and national and international prioritization. An external advisory committee comprising of five members from national and global partners, representatives from SFA and AUDA-NEPAD will provide guidance after review of applications. This is a governance committee that will provide technical support from the time of priority areas decisions, formulating the request for applications (RFA), advise on reviewers, and final advisory information to Board of NRIF Sub-committee for final decisions on awards. The external advisory committee will provide technical support throughout implementation for grants awarded.